NCT06692738 Change History

Timestamp Before After
2026-02-26 00:55:51 statusModule.statusVerifiedDate: 2026-01 statusModule.statusVerifiedDate: 2026-02
2026-02-26 00:55:51 statusModule.lastUpdateSubmitDate: 2026-01-20 statusModule.lastUpdateSubmitDate: 2026-02-24
2026-02-26 00:55:51 statusModule.lastUpdatePostDateStruct.date: 2026-01-21 statusModule.lastUpdatePostDateStruct.date: 2026-02-25
2026-02-26 00:55:51 contactsLocationsModule.locations.[54]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[54]status: RECRUITING
2026-02-26 00:55:51 contactsLocationsModule.locations.[90]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[90]status: RECRUITING
2026-02-26 00:55:51 contactsLocationsModule.locations.[156]status: SUSPENDED contactsLocationsModule.locations.[156]status: RECRUITING
2026-02-26 00:55:51 contactsLocationsModule.locations.[162]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[162]status: RECRUITING
2026-02-26 00:55:51 contactsLocationsModule.locations.[190]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[190]status: WITHDRAWN
2026-02-26 00:55:51 contactsLocationsModule.locations.[194]status: RECRUITING contactsLocationsModule.locations.[194]status: WITHDRAWN
2026-02-26 00:55:51 contactsLocationsModule.locations.[195]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[195]status: WITHDRAWN
2026-02-26 00:55:51 contactsLocationsModule.locations.[211]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[211]status: RECRUITING
2026-04-01 02:42:41 statusModule.statusVerifiedDate: 2026-02 statusModule.statusVerifiedDate: 2026-03
2026-04-01 02:42:41 statusModule.lastUpdateSubmitDate: 2026-02-24 statusModule.lastUpdateSubmitDate: 2026-03-30
2026-04-01 02:42:41 statusModule.lastUpdatePostDateStruct.date: 2026-02-25 statusModule.lastUpdatePostDateStruct.date: 2026-03-31
2026-04-01 02:42:41 contactsLocationsModule.locations.[0]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[0]status: RECRUITING
2026-04-01 02:42:41 contactsLocationsModule.locations.[49]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[49]status: RECRUITING
2026-04-01 02:42:41 contactsLocationsModule.locations.[156]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[156]status: RECRUITING
2026-04-01 02:42:41 contactsLocationsModule.locations.[227]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[227]status: RECRUITING
2026-04-01 02:42:41 contactsLocationsModule.locations.[251]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[251]status: RECRUITING
2026-04-01 02:42:41 - root['contactsLocationsModule']['locations'][274]['zip'] (Added)
2026-04-04 02:21:52 contactsLocationsModule.locations.[202]city: Padua contactsLocationsModule.locations.[202]city: Padova
2026-04-04 02:21:52 contactsLocationsModule.locations.[202]geoPoint.lat: 45.40797 contactsLocationsModule.locations.[202]geoPoint.lat: 44.38225
2026-04-04 02:21:52 contactsLocationsModule.locations.[202]geoPoint.lon: 11.88586 contactsLocationsModule.locations.[202]geoPoint.lon: 11.14261
2026-05-26 02:38:41 statusModule.statusVerifiedDate: 2026-03 statusModule.statusVerifiedDate: 2026-04
2026-05-26 02:38:41 statusModule.lastUpdateSubmitDate: 2026-03-30 statusModule.lastUpdateSubmitDate: 2026-04-30
2026-05-26 02:38:41 statusModule.lastUpdatePostDateStruct.date: 2026-03-31 statusModule.lastUpdatePostDateStruct.date: 2026-05-01
2026-05-26 02:38:41 contactsLocationsModule.locations.[4]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[4]status: RECRUITING
2026-05-26 02:38:41 contactsLocationsModule.locations.[130]geoPoint.lat: 22.8836 contactsLocationsModule.locations.[130]geoPoint.lat: 30.17415
2026-05-26 02:38:41 contactsLocationsModule.locations.[130]geoPoint.lon: 107.264 contactsLocationsModule.locations.[130]geoPoint.lon: 120.97629
2026-05-26 02:38:41 contactsLocationsModule.locations.[276]city: Taoyuan District contactsLocationsModule.locations.[276]city: Taoyuan
2026-05-26 02:38:41 contactsLocationsModule.locations.[276]geoPoint.lat: 24.9896 contactsLocationsModule.locations.[276]geoPoint.lat: 24.99368
2026-05-26 02:38:41 contactsLocationsModule.locations.[276]geoPoint.lon: 121.3187 contactsLocationsModule.locations.[276]geoPoint.lon: 121.29696
2026-05-26 02:38:41 contactsLocationsModule.locations.[279]geoPoint.lat: 13.7775 contactsLocationsModule.locations.[279]geoPoint.lat: 13.77706
2026-05-26 02:38:41 contactsLocationsModule.locations.[279]geoPoint.lon: 100.51977 contactsLocationsModule.locations.[279]geoPoint.lon: 100.51958
2026-05-26 02:38:41 contactsLocationsModule.locations.[282]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[282]status: RECRUITING
2026-05-26 02:38:41 contactsLocationsModule.locations.[283]zip: 07058 contactsLocationsModule.locations.[283]zip: 07059
2026-06-11 04:04:08 statusModule.statusVerifiedDate: 2026-04 statusModule.statusVerifiedDate: 2026-06
2026-06-11 04:04:08 statusModule.lastUpdateSubmitDate: 2026-04-30 statusModule.lastUpdateSubmitDate: 2026-06-09
2026-06-11 04:04:08 statusModule.lastUpdatePostDateStruct.date: 2026-05-01 statusModule.lastUpdatePostDateStruct.date: 2026-06-10
2026-06-11 04:04:08 contactsLocationsModule.locations.[23]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[23]status: WITHDRAWN
2026-06-11 04:04:08 contactsLocationsModule.locations.[50]city: Canton contactsLocationsModule.locations.[50]city: Fort Wayne
2026-06-11 04:04:08 contactsLocationsModule.locations.[50]state: Ohio contactsLocationsModule.locations.[50]state: Indiana
2026-06-11 04:04:08 contactsLocationsModule.locations.[50]zip: 44718 contactsLocationsModule.locations.[50]zip: 46845
2026-06-11 04:04:08 contactsLocationsModule.locations.[50]geoPoint.lat: 40.79895 contactsLocationsModule.locations.[50]geoPoint.lat: 41.1306
2026-06-11 04:04:08 contactsLocationsModule.locations.[50]geoPoint.lon: -81.37845 contactsLocationsModule.locations.[50]geoPoint.lon: -85.12886
2026-06-11 04:04:08 contactsLocationsModule.locations.[34]city: South Portland contactsLocationsModule.locations.[34]city: Scarborough
2026-06-11 04:04:08 contactsLocationsModule.locations.[34]zip: 04106 contactsLocationsModule.locations.[34]zip: 04074
2026-06-11 04:04:08 contactsLocationsModule.locations.[34]geoPoint.lat: 43.64147 contactsLocationsModule.locations.[34]geoPoint.lat: 43.57814
2026-06-11 04:04:08 contactsLocationsModule.locations.[34]geoPoint.lon: -70.24088 contactsLocationsModule.locations.[34]geoPoint.lon: -70.32172
2026-06-11 04:04:08 contactsLocationsModule.locations.[111]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[111]status: RECRUITING
2026-06-11 04:04:08 contactsLocationsModule.locations.[142]status: SUSPENDED contactsLocationsModule.locations.[142]status: RECRUITING
2026-06-11 04:04:08 contactsLocationsModule.locations.[180]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[180]status: RECRUITING
2026-06-11 04:04:08 contactsLocationsModule.locations.[220]status: NOT_YET_RECRUITING contactsLocationsModule.locations.[220]status: RECRUITING
2026-07-28 00:26:06 identificationModule.briefTitle: A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) identificationModule.briefTitle: A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
2026-07-28 00:26:06 identificationModule.officialTitle: A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Metastatic Squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1 (ARTEMIDE-Lung02) identificationModule.officialTitle: A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1 (ARTEMIDE-Lung02)
2026-07-28 00:26:06 statusModule.statusVerifiedDate: 2026-06 statusModule.statusVerifiedDate: 2026-07
2026-07-28 00:26:06 statusModule.primaryCompletionDateStruct.date: 2029-02-05 statusModule.primaryCompletionDateStruct.date: 2030-07-01
2026-07-28 00:26:06 statusModule.completionDateStruct.date: 2029-10-08 statusModule.completionDateStruct.date: 2030-07-01
2026-07-28 00:26:06 statusModule.lastUpdateSubmitDate: 2026-06-09 statusModule.lastUpdateSubmitDate: 2026-07-13
2026-07-28 00:26:06 statusModule.lastUpdatePostDateStruct.date: 2026-06-10 statusModule.lastUpdatePostDateStruct.date: 2026-07-14
2026-07-28 00:26:06 descriptionModule.briefSummary: The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1). descriptionModule.briefSummary: The purpose of ARTEMIDE-Lung02 is to assess the efficacy and safety of rilvegostomig in combination with platinum-based chemotherapy for the first-line (1L) treatment of patients with locally advanced or metastatic squamous non-small cell lung cancer (mNSCLC) whose tumors express programmed death-ligand 1 (PD-L1).
2026-07-28 00:26:06 descriptionModule.detailedDescription: This is a Phase III, two-arm, randomized, double-blind, global, multicenter study assessing the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line (1L) treatment for patients with squamous metastatic non-small cell lung cancer (mNSCLC) whose tumors express PD-L1 (tumor cells (TC) ≥ 1%). descriptionModule.detailedDescription: This is a Phase III, two-arm, randomized, double-blind, global, multicenter study assessing the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line (1L) treatment for patients with squamous locally advanced or metastatic non-small cell lung cancer (mNSCLC) whose tumors express PD-L1 (tumor cells (TC) ≥ 1%).
2026-07-28 00:26:06 designModule.enrollmentInfo.count: 880 designModule.enrollmentInfo.count: 1160
2026-07-28 00:26:06 outcomesModule.primaryOutcomes.[0]timeFrame: Up to approximately 5 years outcomesModule.primaryOutcomes.[0]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.primaryOutcomes.[1]timeFrame: Up to approximately 5 years outcomesModule.primaryOutcomes.[1]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[0]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[0]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[1]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[1]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[2]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[2]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[3]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[3]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[4]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[4]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[5]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[5]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[6]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[6]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[7]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[7]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[8]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[8]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 outcomesModule.secondaryOutcomes.[9]timeFrame: Up to approximately 5 years outcomesModule.secondaryOutcomes.[9]timeFrame: Up to approximately 6 years
2026-07-28 00:26:06 - Field `eligibilityModule.eligibilityCriteria` changed from `Inclusion Criteria:
2026-07-28 00:26:06 - * Histologically or cytologically documented squamous NSCLC.
2026-07-28 00:26:06 - * Stage IV mNSCLC (based on the American Joint Committee on Cancer Edition 8) not amenable to curative treatment.
2026-07-28 00:26:06 - * Absence of documented tumor genomic mutation results from tests conducted as part of standard local practice in any actionable driver oncogenes for which there are locally approved targeted 1L therapies.
2026-07-28 00:26:06 - * Provision of acceptable tumor sample to confirm tumor PD-L1 expression TC ≥ 1%.
2026-07-28 00:26:06 - * At least one lesion not previously irradiated that qualifies as a RECIST 1.1 TL at baseline and can be accurately measured at baseline as ≥ 10 mm in the longest diameter (except lymph nodes, which must have short axis ≥ 15 mm) with CT or MRI and is suitable for accurate repeated measurements.
2026-07-28 00:26:06 - * Adequate organ and bone marrow function.
2026-07-28 00:26:06 - Exclusion Criteria:
2026-07-28 00:26:06 - * Presence of small cell and neuroendocrine histology components.
2026-07-28 00:26:06 - * Brain metastases unless asymptomatic, stable, and not requiring steroids or anticonvuls` to `Inclusion Criteria:
2026-07-28 00:26:06 - * Histologically or cytologically documented squamous NSCLC.
2026-07-28 00:26:06 - * Stage III B/C or IV mNSCLC (based on the American Joint Committee on Cancer Edition 8) not amenable to curative treatment.
2026-07-28 00:26:06 - * Absence of documented tumor genomic mutation results from tests conducted as part of standard local practice in any actionable driver oncogenes for which there are locally approved and available targeted 1L therapies.
2026-07-28 00:26:06 - * Provision of acceptable tumor sample to confirm tumor PD-L1 expression TC ≥ 1%.
2026-07-28 00:26:06 - * At least one lesion not previously irradiated that qualifies as a RECIST 1.1 TL at baseline and can be accurately measured at baseline as ≥ 10 mm in the longest diameter (except lymph nodes, which must have short axis ≥ 15 mm) with CT or MRI and is suitable for accurate repeated measurements.
2026-07-28 00:26:06 - * Adequate organ and bone marrow function.
2026-07-28 00:26:06 - Exclusion Criteria:
2026-07-28 00:26:06 - * Presence of small cell and neuroendocrine histology components.
2026-07-28 00:26:06 - * Brain metastases unless asymptomatic, stable, and not requirin`
2026-07-28 00:26:06 contactsLocationsModule.locations.[36]status: RECRUITING contactsLocationsModule.locations.[36]status: COMPLETED
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]status: RECRUITING contactsLocationsModule.locations.[40]status: NOT_YET_RECRUITING
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]city: Duluth contactsLocationsModule.locations.[40]city: Saginaw
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]state: Minnesota contactsLocationsModule.locations.[40]state: Michigan
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]zip: 55802 contactsLocationsModule.locations.[40]zip: 48602
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]geoPoint.lat: 46.78327 contactsLocationsModule.locations.[40]geoPoint.lat: 43.41947
2026-07-28 00:26:06 contactsLocationsModule.locations.[40]geoPoint.lon: -92.10658 contactsLocationsModule.locations.[40]geoPoint.lon: -83.95081
2026-07-28 00:26:06 contactsLocationsModule.locations.[41]city: Rochester contactsLocationsModule.locations.[41]city: Duluth
2026-07-28 00:26:06 contactsLocationsModule.locations.[41]zip: 55905 contactsLocationsModule.locations.[41]zip: 55802
2026-07-28 00:26:06 contactsLocationsModule.locations.[41]geoPoint.lat: 44.02163 contactsLocationsModule.locations.[41]geoPoint.lat: 46.78327
2026-07-28 00:26:06 contactsLocationsModule.locations.[41]geoPoint.lon: -92.4699 contactsLocationsModule.locations.[41]geoPoint.lon: -92.10658
2026-07-28 00:26:06 contactsLocationsModule.locations.[42]city: Bridgeton contactsLocationsModule.locations.[42]city: Rochester
2026-07-28 00:26:06 contactsLocationsModule.locations.[42]state: Missouri contactsLocationsModule.locations.[42]state: Minnesota
2026-07-28 00:26:06 contactsLocationsModule.locations.[42]zip: 63044 contactsLocationsModule.locations.[42]zip: 55905
2026-07-28 00:26:06 contactsLocationsModule.locations.[42]geoPoint.lat: 38.767 contactsLocationsModule.locations.[42]geoPoint.lat: 44.02163
2026-07-28 00:26:06 contactsLocationsModule.locations.[42]geoPoint.lon: -90.41151 contactsLocationsModule.locations.[42]geoPoint.lon: -92.4699
2026-07-28 00:26:06 contactsLocationsModule.locations.[43]status: WITHDRAWN contactsLocationsModule.locations.[43]status: RECRUITING
2026-07-28 00:26:06 contactsLocationsModule.locations.[43]city: Columbia contactsLocationsModule.locations.[43]city: Bridgeton
2026-07-28 00:26:06 contactsLocationsModule.locations.[43]zip: 65212 contactsLocationsModule.locations.[43]zip: 63044
2026-07-28 00:26:06 contactsLocationsModule.locations.[43]geoPoint.lat: 38.95171 contactsLocationsModule.locations.[43]geoPoint.lat: 38.767
2026-07-28 00:26:06 contactsLocationsModule.locations.[43]geoPoint.lon: -92.33407 contactsLocationsModule.locations.[43]geoPoint.lon: -90.41151
2026-07-28 00:26:06 contactsLocationsModule.locations.[44]status: RECRUITING contactsLocationsModule.locations.[44]status: WITHDRAWN
2026-07-28 00:26:06 contactsLocationsModule.locations.[44]city: Kansas City contactsLocationsModule.locations.[44]city: Columbia
2026-07-28 00:26:06 contactsLocationsModule.locations.[44]zip: 64108 contactsLocationsModule.locations.[44]zip: 65212
2026-07-28 00:26:06 contactsLocationsModule.locations.[44]geoPoint.lat: 39.09973 contactsLocationsModule.locations.[44]geoPoint.lat: 38.95171
2026-07-28 00:26:06 contactsLocationsModule.locations.[44]geoPoint.lon: -94.57857 contactsLocationsModule.locations.[44]geoPoint.lon: -92.33407
2026-07-28 00:26:06 contactsLocationsModule.locations.[45]city: Lincoln contactsLocationsModule.locations.[45]city: Kansas City
2026-07-28 00:26:06 contactsLocationsModule.locations.[45]state: Nebraska contactsLocationsModule.locations.[45]state: Missouri
2026-07-28 00:26:06 contactsLocationsModule.locations.[45]zip: 68506 contactsLocationsModule.locations.[45]zip: 64108
2026-07-28 00:26:06 contactsLocationsModule.locations.[45]geoPoint.lat: 40.8 contactsLocationsModule.locations.[45]geoPoint.lat: 39.09973
2026-07-28 00:26:06 contactsLocationsModule.locations.[45]geoPoint.lon: -96.66696 contactsLocationsModule.locations.[45]geoPoint.lon: -94.57857
2026-07-28 00:26:06 contactsLocationsModule.locations.[46]city: Camden contactsLocationsModule.locations.[46]city: Lincoln
2026-07-28 00:26:06 contactsLocationsModule.locations.[46]state: New Jersey contactsLocationsModule.locations.[46]state: Nebraska
2026-07-28 00:26:06 contactsLocationsModule.locations.[46]zip: 08103 contactsLocationsModule.locations.[46]zip: 68506
2026-07-28 00:26:06 contactsLocationsModule.locations.[46]geoPoint.lat: 39.92595 contactsLocationsModule.locations.[46]geoPoint.lat: 40.8
2026-07-28 00:26:06 - Field `contactsLocationsModule.locations.[46]geoPoint.lon` changed from `-75.11962` to `-96.6